Information in this section pertains to all global PEN® partners except where country flags are
visible. Click on the flag(s) for country-specific information. If a country flag is not listed, there is
no information specific to that country.
[A] The following conclusions are supported by good evidence:
Clinical trials have demonstrated that oral folic acid supplementation (1 mg/day) given to individuals with rheumatoid arthritis (RA) who are taking methotrexate (MTX), can reduce adverse effects of MTX therapy, notably liver toxicity. Folic acid supplements (5 mg/week) taken one day after MTX administration have been recommended.
Based on clinical trials, it is recommended that individuals with RA receiving any dose of